This is a randomized, controlled clinical study evaluating the abnormal windows 10 key sale circadian blood pressure pattern in insulin dependent diabetic (IDDM) patients and its response to APS. 74 IDDM patients were randomized to a treatment (APS) group or a control group. 24 hour blood pressure monitoring was performed monthly along with buy Windows.. read more →

This is a multi-center, retrospective, longitudinal study, involving 31 patients with type 1 diabetes mellitus and overt diabetic nephropathy. All patients were on intensive (four daily shots) insulin therapy and weekly APS. All patients were on ACE therapy and aggressive antihypertensive regimens. All patients were followed with creatinine clearance measurements. Patients were followed for an.. read more →

This is a prospective, randomized, crossover study, examining antihypertensive medication requirements in 26 hypertensive insulin dependent diabetic patients. These patients were randomized intotreatment and control groups. All patients were stabilized prior to the study on four shots of insulin daily and antihypertensive medications (ACE inhibitors, calcium channel blockers, loop diuretics, and alpha two agonists). Following.. read more →

This study examined 20 “brittle” diabetics (defined as patients with wide glucose swings and frequent hypoglycemic episodes) treated with the APS protocol. This was a prospective study with patients serving as their own historic controls. All patients had been on intensive insulin therapy (four shots daily) for at least one year prior to entrance into.. read more →

Artificial Pancreas System Therapy (APS) is a process which promotes the normalization of carbohydrate metabolism in diabetic patients. APS affects multiple organs, especially muscle, retina, liver, kidney, and nerve endings. The process involves the administration of insulin pulses similar to those found in the portal circulation of normal humans using the Bionica MicroDose which is FDA.. read more →

Normally, insulin is secreted almost exclusively in a pulsatile fashion, in amounts closely related to the intake of meals. The pulses of insulin coupled with the presence of glucose, provides the necessary two signals to the liver for proper carbohydrate metabolism, whereas in comparison, continuous insulin infusion does not. In fact, continuous exposure to insulin.. read more →